A 99mTc-labelled scFv antibody fragment that binds to prostate-specific membrane antigen
نویسندگان
چکیده
منابع مشابه
A 99mTc-labelled scFv antibody fragment that binds to prostate-specific membrane antigen
INTRODUCTION Prostate-specific membrane antigen (PSMA) is an extensively studied antigen for imaging prostate cancer. We prepared a single-chain variable fragment (scFv) of J591, a monoclonal antibody that recognises an external epitope of PSMA, incorporating a His-tag for labelling with Tc tricarbonyl, and evaluated its binding using human PCa cell lines. METHODS J591(scFv) was expressed in ...
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ژورنال
عنوان ژورنال: Nuclear Medicine Communications
سال: 2017
ISSN: 0143-3636
DOI: 10.1097/mnm.0000000000000698